ABSTRACT
Objective To investigate clinical efficacy of the NB-UVB phototherapy combined with calcipotriol ointment and halometasone cream in the treatment of psoriasis.Methods 90 patients with psoriasis were selected and randomly divided into control group and observation group with 45 cases of patients.In both two groups,calcipotriol ointment,1 time/d,were used combined with halometasone cream,1 time/d,with a total of 4 weeks.On the basis of these,patients of observation group were added NB-UVB phototherapy (Germany Waldmann7001K ultraviolet light therapy device),1 time every other day with starting dose of 0.5J/cm2,each increment of 0.1J/cm2,for treatment of 15 times.Before and after treatment in patients of two groups,PASI score and clinical efficacy were observed.Visual analogue scale (VAS) were was used to observe itching skin lesions before and after treatment.By using Dermatology Life Quality Index (DLQI),qualities of life in two groups of patients before and after treatment were evaluated.observe two patients before and after treatment expression levels of serum IL-17A,IL-22 and IL-1βwere also observed in patients of the two groups.Results The total efficiency of the observation group was 88.89％,which of the control group was 80.00％,the clinical efficacy of the observation group which was higher than that of the control group,and the difference was statistically significant (x2 =5.23,P ＜ 0.05).Before treatment,the difference of PASI,VAS score and DLQI in the two groups of patients were not statistically significant (P ＞ 0.05).After treatment,scores in the two groups of patients were significantly decreased,and the degree of decrease in the observation group was higher than the control group,the difference was significant (P ＜ 0.05).Before treatment,the differences in serum IL -17A,IL-22 and IL-1β expression levels of both two groups were not statistically significant (P ＞0.05).After treatment,these expression levels of the two groups of patients decreased significantly,and the decreased of observation group was more significantly than that of the control group (P ＜ 0.05).Conclusion NB-UVB phototherapy combined with calcipotriol ointment and halometasone cream in treatment of psoriasis vulgaris patients can significantly improve patients' skin lesions,and can improve patients' quality of life score,which is worthy of promotion.
ABSTRACT
Objective To explore the application of BCG polysaccharide nucleic acid injection in the treatment of skin diseases.Methods Selected in June 2015 to August 2016 period, in our hospital for skin disease treatment of 200 patients. According to the type of skin disease is divided into chronic eczema, chronic urticaria, alopecia areata and flat warts four groups, each group contains 50 patients. And then each group of patients were randomly divided into two groups, one group as a control group, a group as the observation group, each group of 25 cases. The control group was treated with traditional drug therapy, and the observation group needed to increase the use of BCG polysaccharide nucleic acid injection. The treatment period is for three months. To observe and compare the treatment effect of the control group and the experimental group after three months, that is, to observe and compare patients with chronic eczema, chronic urticaria, alopecia areata and flat warts of the four different types of skin diseases after three months of treatment effect. Results In the patients with chronic eczema, the effective rate of treatment was 96.0％ in the observation group and 68.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The effective rate was 88.0％ in the observation group and 60.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the patients with alopecia areata, The effective rate of treatment was 84.0％ in the observation group and 72.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the patients with flat warts, The effective rate was 92.0％ and the effective rate was 68.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the different types of skin diseases, the effective rate of treatment was obvious Higher than the control group, the treatment effect was significantly better than the control group (P<0.05). Conclusion For patients with skin diseases using BCG polysaccharide nucleic acid injection for treatment, compared to the traditional drug treatment better. For the different types of skin diseases, the use of BCG polysaccharide nucleic acid injection for treatment can get the best therapeutic effect, so BCG polysaccharide nucleic acid injection in different types of skin disease clinical treatment is a worthy of use and Its promotion of the treatment.